The agency quickly slapped down the comments from Kirsch, a tech mogul with a fortune once estimated at $230 million, even as the claims triggered a flurry of false social-media posts attributing. Please. So it was both obvious and convincing the difference between the groups to the workers and the track management. Weve known it works since August 24, 2020. There is no evidence fluvoxamine is harmful and led to a worse outcome. 21. Early treatment with existing drugs is the fastest, most effective, and lowest. Medicine today isnt about saving your life. Boulwares trial was part of a wider movement to bulk up the evidence base underlying standard covid treatments, and one of several trials that found no benefit to using hydroxychloroquine. It is perhaps the greatest unnecessary loss of life in American history. and here are the slides I used in, Collections of op-eds and presentations about fluvoxamine, Please see my answer on Quora Sage Hana. 90,000 Americans will die from COVID in just the next 3 weeks, a third of recovered patients from COVID will return to the hospital within 5 months and 1 in 8 die, Lenze fluvoxamine RCT that was published in JAMA. 707. . Substitutions. People who report not tolerating the drug are typically prescribed too high a dose. After boosting unproven covid drugs and campaigning against vaccines, Steve Kirsch was abandoned by his team of scientific advisersand left out of a job. This give another 50% of benefit. Some people report mild nausea while on the drug (stops when stop the drug). The sooner you start, the better the outcomes. So it was both obvious and convincing the difference between the groups to the workers and the track management. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital security (OneID), or e-commerce (Propel Software). That trial has now been completed, and the researchers are analyzing their data. Dr. Eric Lenze: So the results were really pretty. Hes also made several videos and podcasts with Vladimir Zelenko, the conspiracy theorist doctor who convinced Trump to take hydroxychloroquine. Zero. A very short op-ed arguing for using fluvoxamine against COVID. When the pandemic started, he created the COVID-19 Early Treatment Fund (CETF) to fund researchers working on repurposed drugs including fluvoxamine which reduces death from COVID by a factor of 12. It doesnt get much better than that. thinks it should be used (and that the NIH is wrong for waiting for more clinical trials). I couldn't agree more. Today, we are letting people drown and we are not even telling them there is a life preserver they can ask for today with compelling evidence that is under consideration by the life preserver safety group. It is about following orders and making money for the drug companies and protecting the doctor from liability and losing his medical license. The FDA is will take months to deliberate on the fluvoxamine EUA application that we submitted on January 29. It could do nothing. You can help by bringing this document to your doctor's attention. Think about it Molnupiravir has a 50% risk reduction whereas fluvxoamine is over 90%. There is absolutely no evidence that either one of these claims is true, as Morris has carefully documented. . Hes also publicly railed against what he claims is a campaign against drugs like fluvoxamine and ivermectin. Thats what creates some of these heroes.. Elsewhere he has said he began questioning vaccine safety after an unnamed Twitter follower told him several family members died after getting their shots. [https://www.quora.com/What-is-the-current-treatment-for-Covid-19/answer/, The most urgent need in the country right now is to reduce. Part of TV News Archive. He started 7 high tech companies, two with billion dollar market caps. Here is the latest version. See my article on treatments. Steve Kirsch is a high-tech serial entrepreneur based in Silicon Valley. Online Status. He felt like he in good conscience had to speak out about covid, and so he made the decision to separate himself from M10, says Char, who has known Kirsch since the 1980s. Nobody who took the drug got sick at all, most all wanted to return to work within 3 days after starting treatment. Steve Kirsch. . Expect similar things to happen when Eiger applies for an EUA for interferon lambda, a drug with a 89% efficacy in phase 3 trials. My crime? Steve Kirsch cut the check, which allowed Dr. Lenze to finish recruiting the 152 patients he needed for his trial. Some speaker, off camera, went on a . According to its founder, serial tech entrepreneur Steve Kirsch, CETF was started in April 2020 in order to fund. He started a new pseudonymous account, @VaccineTruth2, to continue broadcasting messages. The board members I spoke to say they refused to publicly promote any drugs for off-label use and tried to explain to Kirsch that its incredibly common for exciting results from small trials to disappear in larger ones. The ongoing battle between social-media companies and covid-19 misinformation pushersincluding US president Donald Trumpstepped up again this week thanks to a new viral video. Unfortunately, as Jeffrey Morris at UPenn points out, public health officials and scientists have done plenty to undermine their own authority, like claiming masks dont work, downplaying the natural immunity conveyed by previous covid infections, and not doing enough public communication about vaccine safety surveillance systems. He thinks # killed by vax could be anywhere between 0 and 150K people dead.. But they will refuse to give it to you even after being proven in a Phase 3 trial that was approved by the WHO. Get your prescription in advance of getting COVID. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. My favorite dosage is 50mg twice a day for 14 days. But even that didnt last long. Paper reviewing the evidence and mechanisms of action for fluvoxamine: Lenze Phase 2 RCT published Nov 12, 2020: Seftel RWE trial that confirmed the Phase 2 trial published Feb 1, 2021. By Steve Kirsch Mar 14, 2021 Fluvoxamine, Proxalutamide, and Ivermectin: 100% success I'm very bullish on two drug combos since it is rare for a single drug to be 100% successful. The data we have today with just 2 clinical trials (RCT and confirmatory RWE) is compelling. At the end of May this year, Siliciano emailed the other advisors to say that Kirsch had gone off the deep end and he was cutting ties. He's founded 7 companies, 2 with billion dollar valuations. If you cant get a prescription for COVID, then perhaps you have OCD? On January 22, 2021, thirty key opinion leaders (KOL) from NIH, CDC, and leading academic institutions met to review the evidence for using fluvoxamine for treating COVID. Generally, at 50mg BID x 14, it is very tolerable as long as the patient is instructed to lay off the caffeine. In three phone conversations, as well as dozens of emails, his responses to questions about claims in this story were imprecise or constantly changing. When I asked him why so many experts in the field disagreed with him, he alleged there were effortseither malicious or negligentto suppress evidence of cheap, effective covid treatments. He told me that while he and his family got vaccinated as soon as they were eligible, he got the idea that vaccines are dangerous from a man he hired to clean his carpets, who got very sick after receiving the vaccine. Nobody in the medical community is speaking out about how hypocritical the medical community is for ignoring the positive Phase 3 trial results and instead following whatever the NIH or FDA says. The 50mg BID dose was quite effective, but it has to be started early (as soon as symptoms start). We pretty much practice government agency opinion medicine all over the world now, with just a few exceptions. There were no studies reported out so far where fluvoxamine made things worse or neutral. Dosage there is 30mg once a day. Then he hosted a superspreader event. He started a covid-19 vaccine company. Mouse Systems is not a household word, he told the journalist. There were no studies reported out so far where fluvoxamine made things worse or neutral. They knew in advance it was coming and on the day the paper was published they ignored it entirely. In September, Kirsch emailed Morris asking him to estimate the maximum number of deaths caused by vaccines. Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI), a class of anti-depressants, mostly prescribed for people suffering from an obsessive-compulsive disorder. Dr. Seftel's paper has been accepted for publication and will appear in OFID in early February. We should not wait for the Phase 3 RCT. Stopping the meds will return you to your normal self. You can use fluoxetine as well (aka Prozac). If you start later, doctors use higher dosages and compliance becomes a bigger problem. All the supporting observational studies were positive as well. In short, a lot of mumbo jumbo. In May, all 12 members of CETFs scientific advisory board resigned, citing his alarming dangerous claims and erratic behavior. There are other non-prescription things you should always have on hand. Everyone says "we need more data" to show fluvoxamine works for COVID. It was approved by the FDA in 1994 and has been used in millions of patients worldwide. If you have trouble getting a prescription, perhaps you have OCD? 1 hr ago. The study was also featured on 60 Minutes. The sooner you start, the better the outcomes. So check the side-effects list to be familiar with which side-effects are associated with which drug so if you have a side-effect, youll know which drug to reduce or eliminate. Fluvoxamine has a 40 year safety track record. The babys brain was split in half, and it was just covered with blood. 4000fluvoxamine750 In two trials (both published studies in peer reviewed journals with Editor's Choice in both cases), the drug had a 100% effect size in protecting against hospitalization from the respiratory symptoms from COVID. The man who ran Risperdal sales, Alex Gorsky, is now CEO of Johnson & Johnson. He's discovered a common medication that's highly effective in minimizing the impacts of COVID-19 - two studies have proven so. The. If you cant lay off the java, then try fluoxetine (Prozac). @stkirsch. Completely avoid caffeine, alcohol, tylenol, and benadryl. He has made millions from these projects, even if they have not turned him into a household name. But not 150K. This should be top news, but the press is ignoring this and attempt to write stories about it are killed by the editors. Although there is evidence that fluvoxamine can prevent clinical worsening and the need for hospitalizations in outpatients with early covid-19, I have seen no good evidence that fluvoxamine is useful as a substitute for the vaccines, co-investigator Angela Reiersen wrote to me. Fluvoxamine is a selective serotonin reuptake inhibitor (SSRI), a class of anti-depressants, mostly prescribed for people suffering from an obsessive-compulsive disorder. The group who declined the drug were very sick with 12.5% requiring hospitalization and one died. Mar. Nobody who took the drug got sick at all, most all wanted to return to work within 3 days after starting treatment. Fluvoxamine is way better than Molnupiravir, but the NIH doesnt approve drugs on effectiveness. The medical community did nothing (with a few exceptions like Dr. Seftel). 47).. Jeffrey Morris, director of biostatistics at the University of Pennsylvania Perelman School of Medicine, has made debunking Kirschs claims something of a hobby. And he wont talk to you either if you ask nosy questions like Cliff, my risk benefit analysis shows you should be rushing to recommend this drug. Ive used it personally at 50mg twice a day and experience no adverse events at all. Doctors are afraid that even with a 37-year safety record of this drug, that something will go terribly wrong and they will be blamed. Kirsch IDeacon BJHuedo-Medina TBScoboria AMoore TJJohnson BT Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration. During our first conversation, which turned into a multi-hour Zoom session, Kirsch paced through the rooms of his cavernous house with his phone held at chest level, rarely looking down at the camera. In October, the group reported that, while a few patients in the placebo group ended up in the hospital, none of the patients receiving fluvoxamine got sick enough to go. Author Affiliations Article Information. By Steve Kirsch in fluvoxamine Feb 14, 2021 The case for fluvoxamine for treating COVID-19 A very short op-ed arguing for using fluvoxamine against COVID. Thanks to the volumes of data and information provided by pharmaceutical companies and regulators, as well as large numbers of trials from independently funded research groups around the world, I now trust that theyre safe for the vast majority of adults. Steve Kirsch reported that doctors commonly say (of fluvoxamine), "This is the most powerful drug in my arsenal. In every case we are aware of, the drug was successful in reversing COVID symptoms, generally in 3 days or less. The premise made sense: Most experts were predicting vaccines would take years, while finding helpful drugs with known safety profiles could shortcut the approval process. Also, this drug is only prescribed by psychiatrists so most doctors have no experience whatsoever with the drug. Its not about the science. This document is a collection of evidence that highlights the glaring errors in our pandemic response. That covers almost 150,000 of them, which happened before vaccinations began. I have all of these on hand and I load up on vitamin D3 every day. JAMA systematic review and meta analysis It doesnt get any better than this. The repository goes over the prescribing guidelines, contraindications, and describes the effect on caffeine consumption while on drug (basically you want to avoid caffeine while on the drug). Hes also recently increased the number of Americans he claim have been killed by the vaccine from 25,0000, to 150,000, or even as many as 250,000 Americans. If you continue to get this message, 12:45 AM . There are 4 outpatient studies that have been done (2 at WashU (see Phase 2 trial results published in JAMA), one in Berkeley, CA by David Seftel, one in Brazil published in the Lancet, and one in-patient study done in Croatia. (Siliciano did not respond to requests for comment for this article.). . Think about it Molnupiravir has a 50% risk reduction whereas fluvxoamine is over 90%. If you do have a side-effect, it is usually mild nausea which goes away when you stop taking the drug. Kirsch is a serial entrepreneur who has spent decades pitching the next big thing, whether optical mice (Mouse Systems), document processing (FrameMaker), search engines (Infoseek), digital. In it, he claimed mRNA vaccines kill one in 5,000 recipients and dramatically increase the rate of miscarriages. CETF funded David Boulware's trials on hydroxychloroquine and the Phase 2 and Phase 3 fluvoxamine trials, among many other research projects. If you wanna find someone to debate me for ten thousand dollars, or a thousand dollars, Im happy to do that, just for your benefit.. Hilary Grant-Valdez Operations Manager Tom Brunner My publicly shared concerns regarding the safety of the COVID-19 vaccines may have had a negative impact on my company, M10. While Kirsch had the final say in who received grants, no one I spoke with expressed concerns about what projects had been funded, or why. Links to evidence about fluvoxamine including the public data repository. He applied the drug to a large COVID outbreak at Golden Gate Fields just days after the Lenze trial was published. Answer (1 of 2): Yes, In a preliminary study of COVID-19 patients with mild-to-moderate disease who were attempting to recover in their homes, researchers at Washington University School of Medicine in St. Louis have found that the drug fluvoxamine seems to prevent some of the most serious compli. I fully expected both organizations to do absolutely nothing. Here are the key things you should know about fluvoxamine for COVID: It works. O, Platelet reactivity to thrombin differs between patients with COVID-19 and those with ARDS unrelated to COVID-19 | Blood Advances | American Society of Hematology, Fluvoxamine for COVID-19 summary Steve Kirsch Executive Director COVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008, Fluvoxamine for COVID-19 Steve Kirsch Executive Director COVID-19 Early Treatment Fund stk@treatearly.org 650-279-1008, Drug Repurposing Research Leads to Potentially Game-Changing Treatment to Prevent Clinical Deterioration in Outpatients With COVID, The Covid-19 Early Treatment Fund was launched to provide funding for research in order to, Steve Kirschs answer to What is the current treatment for Covid-19? In-patient use. If you are experiencing any odd adverse reactions, youll need to consult with your doctor ASAP. Those days are gone. A very short op-ed arguing for using fluvoxamine against COVID. Medicine has been transformed to doing whatever the NIH/FDA says, regardless of how many lives will be lost. You will be wired for 24 hours if you dont heed my advice. He may not be a good scientist, but hes smart, says WVUs Feinberg. Consider masks by contrast. Skirsch.io site visitors volume is 1,957 unique day-to-day guests and their 3,914 pageviews. 36m "We found Fauci was the most highly compensated federal employee. The NIH Guidelines committee is being very slow to react (we have no idea if they are even considering the drug because nobody is allowed to know that because all their deliberations are kept secret). From the French observational data (see the very last page), it appears that the biggest effect is limiting serotonin release (any SSRI will do that). All the researchers are convinced the drug works. Nov 12: Steve Kirsch gives talk on CETF to HarvardBusiness School hosted by Dr. Seftel Nov 13:Mass COVID outbreak at GGF is now publiclyknown Nov 16: Seftel, the track physician at GGF, startsFLV . Try refreshing this page and updating them one this is NOT about the science. We don't know why the NIH panel is ignoring fluvoxamine and we aren't allowed to find out. But a panel of key opinion leaders from the NIH, CDC . Fluvoxamine - The backstory T he i nsi de st ory behi nd how f l uvoxami ne became a CO V I D t herapy By Steve Kirsch Last updated: June 3, 2021 . Yes, these were successes, but the successes could have been bigger if we had really paid attention to marketing. NIH is still unsure whether fluvoxamine should be used to treat COVID (article I did after the TOGETHER trial). Doctors wait for government permission (EUA or added to the NIH guidelines) before using a drug. Note that some of these articles are inaccurate. It is an amazing drug and is a very simple safe way to avoid long-haul COVID symptoms. Can I see your risk-benefit analysis?. has tons of info on fluvoxamine with all the links. But as Kirsch has clashed with the experts he initially surrounded himself with, hes grown increasingly close to others who share his perspectives on vaccineswho have, in turn, provided a large and receptive audience to his claims about a fluvoxamine conspiracy. . I have never heard of a case it didn't work. Other drugs in this class include Prozac (fluoxetine), Zoloft (sertraline) and Paxil (paroxetine). Late in the session, minutes before this impromptu video wrap up, Tip o' Spear Steve Kirsch addressed the panel and revealed that the FDA had just shot down Fluvoxamine as an approved COVID treatment. Both of them encouraged anyone reading this article to get vaccinated. No one has been able to come up with an example where phase 2 + this level of evidence resulted in a failure of Phase 3. No long haul symptoms if you start the drug ASAP after first symptoms. How can the FDA say a drug which meets the gold standard of evidence has insufficient evidence? Eventually, a press representative who was listening in, David Satterfield, unmuted his microphone to suggest we finish our conversation by email. Its actually much harder to parse out a signal than if youre treating diabetes or cancer., In addition to the issues with fluvoxamine, advisors grew increasingly uncomfortable with Kirschs posts about ivermectin, which he has repeatedly claimed in blog posts and appearances in alternative media can be used together with fluvoxamine to prevent 100% of covid-19 deaths. The NIH did nothing despite the fact the that NIH, FDA, CDC, and academic institutions participated in the panel, this is NOT about the science.